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The administration of trigonelline resulted in a considerable upregulation of the expression of BAT signature proteins, including PGC-1α, PRDM16, and UCP1 as well as the genes that encode these proteins (Ppargc1α, Prdm16, and Ucp1) in 3T3-L1 white adipocytes (Choi et al., 2021)

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Clinical trial participants reported improved sleep patterns after the adjustment period, with 73% noting better overall rest quality by week 12